Avoid or Use Alternate Drug. Tell your doctor all medications and supplements you use. Avoid or Use Alternate Drug. Half-life. e5;O"]rQR8ku:mw/CYux:s8ofW`KMb`! It works by relaxing and widening blood vessels so blood can flow more easily to the heart.This medication will not relieve chest pain once it occurs. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Brand names: Dilatrate, Imdur, Ismo, Isordil, Monoket Drug class: Nitrates and Nitrites VA class: CV250 Chemical name: d-Glucitol-1,4:3,6-dianhydrodinitrate Molecular formula: C 6 H 8 N 2 O 8 C 6 H 9 NO 6 . Your doctor may recommend treating headaches with an over-the-counter pain reliever (such as acetaminophen, aspirin). Reliable assay techniques for plasma nitroglycerin levels have only recently become available, and studies using these techniques to define the pharmacokinetics of nitroglycerin ointment have not been reported. Monitor Closely (1)duvelisib will increase the level or effect of isosorbide mononitrate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Increase dose of CYP3A4 substrate, as needed, when coadministered with cenobamate. Adjust dosage of CYP3A4 substrates, if clinically indicated. Copyright 2023, Selected Revisions February 7, 2017. Comment: Local anesthetics may increase the risk of developing methemoglobinemia when concurrently exposed to drugs that also cause methemoglobinemia. AdultsAt first, 30 or 60 milligrams (mg) once a day. Importance of instructing patients receiving isosorbide dinitrate for relief of acute attacks of angina pectoris to consult a clinician or go to a hospital emergency room immediately if chest pain is not relieved after 3 doses approximately every 5 minutes, because inability to relieve chest pain may indicate acute MI. Monitor sensitive CYP3A4 substrates for effectiveness if coadministered. Administer extended-release tablets with adequate amounts of fluid (e.g., 120 mL) on arising in the morning. Importance of consulting clinician if headache continues with repeated dosing. Mechanism: additive vasodilation. Maximum 40 mg of isosorbide dinitrate and 75 mg of hydralazine hydrochloride (2 tablets of BiDil) 3 times daily. This document does not contain all possible drug interactions. Contraindicated (1)isosorbide mononitrate, avanafil. Tecovirimat is a weak CYP3A4 inducer. Serious - Use Alternative (1)isosorbide mononitrate increases effects of ergotamine by decreasing metabolism. Both drugs lower blood pressure. Importance of informing clinicians of existing or contemplated concomitant therapy, including prescription and OTC drugs as well as any concomitant illnesses. When isosorbide dinitrate is used in fixed combination with hydralazine, consider the cautions, precautions, and contraindications associated with hydralazine. Modify Therapy/Monitor Closely. Monitor Closely (1)stiripentol, isosorbide mononitrate. Conventional oral tablets: 25% unchanged drug; about half that following sublingual administration (4050%). IMDUR Extended Release Tablets should not be chewed or crushed and should be swallowed together with a half-glassful of fluid. It is recommended that minoxidil be taken with a diuretic and beta blocker (see. Consider increasing CYP3A substrate dose if needed. Isosorbide dinitrate in fixed combination with hydralazine hydrochloride: About 2 hours. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. drip: 3-5 minutes. ), Increase dose at an interval of 3 - 5 days, Food increases absorption. Principal pharmacologic property is relaxation of vascular smooth muscle, resulting in generalized vasodilation. Use Caution/Monitor. Use Caution/Monitor. Vasodilatory effect on arteriolar resistance is not as great as the action on the venous side; as a result of this combined action, both venous filling pressure (preload) and, to a lesser extent, arterial impedance (afterload) are reduced. Arteriolar relaxation reduces systemic vascular resistance, systolic arterial pressure, and mean arterial pressure (afterload). Rutherford JD. Consider dose reduction of sensitive CYP3A4 substrates. Coadministration of encorafenib with sensitive CYP3A4 substrates may result in increased toxicity or decreased efficacy of these agents. Do Not Copy, Distribute or otherwise Disseminate without express permission. Heart Disease: Symptoms, Signs, and Causes. Isosorbide mononitrate extended-release tablets, peak: 34.5 hours. Isosorbide dinitrate or mononitrate can be used alone or in combination as either second-line or third-line therapy in patients previously treated with a -blocker. Monitor Closely (1)iloperidone increases levels of isosorbide mononitrate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. affecting hepatic/intestinal enzyme CYP3A4 metabolism. RxList does not provide medical advice, diagnosis or treatment. Avoid or Use Alternate Drug. Use Caution/Monitor. Serious - Use Alternative (1)lofexidine, isosorbide mononitrate. Most Use Caution/Monitor. Avoid or substitute another drug for these medications when possible. To help you remember, take it at the same times each day. Eccentric dosing with isosorbide-5-mononitrate in angina pectoris. Growing cells of Tetrahymena thermophila (T. t.) metabolized, after 72 h, 80% of isosorbide dinitrate (ISDN) to isosorbide 5-mononitrate (5-ISMN) and isosorbide 2-mononitrate (2-ISMN) in a ratio 5-ISMN/2-ISMN=2.6 as evaluated by HPLC. IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. Cobicistat is a CYP3A4 inhibitor; contraindicated with CYP3A4 substrates for which elevated plasma concentrations are associated with serious and/or life-threatening events. Risk of increased SBP, angina pectoris. Mechanism: additive vasodilation. Encorafenib both inhibits and induces CYP3A4 at clinically relevant plasma concentrations. Avoid coadministration with sensitive CYP3A4 substrates with a narrow therapeutic index. Istradefylline 40 mg/day increased peak levels and AUC of CYP3A4 substrates in clinical trials. Many people using this medication do not have serious side effects.Tell your doctor right away if you have any serious side effects, including: fainting, fast/irregular/pounding heartbeat.A very serious allergic reaction to this drug is rare. Individual plans may vary Complete avoidance may not be possible, provided sufficient time elapses between use of the drugs. Mechanism: additive vasodilation. Squeeze the necessary amount of ointment from the tube onto the applicator, place the applicator (ointment side down) on the desired area of the skin, and tape the applicator into place. Imdur (isosorbide mononitrate) Extended Release and Isordil (isosorbide dinitrate) are vasodilators indicated for the prevention of angina pectoris due to coronary artery disease. After removing patch, skin may feel warm and appear red. stiripentol, isosorbide mononitrate. fosphenytoin will decrease the level or effect of isosorbide mononitrate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Rapid titration (over 35 days) may be possible; however, slower titration may be needed due to adverse effects. Do not stop taking it without consulting your doctor. Patients who fail to respond to nitroglycerin lingual or sublingual: 2.55 mg of isosorbide dinitrate. Monitor Closely (1)isosorbide mononitrate, captopril. Supplementary sublingual nitroglycerin doses should be given if necessary during dosage reduction. Modify Therapy/Monitor Closely. isosorbide mononitrate increases effects of cabergoline by decreasing metabolism. This information is not individual medical advice and does not substitute for the advice of your health care professional. For oral dosage form (tablets): Adults20 milligrams (mg) two times a day. stream Monitor Closely (1)conivaptan will increase the level or effect of isosorbide mononitrate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Encorafenib both inhibits and induces CYP3A4 at clinically relevant plasma concentrations. 4, 7 Isosorbide mononitrate is an active metabolite of isosorbide dinitrate. Use Caution/Monitor. Each drug may cause hypotension. Voxelotor increases systemic exposure of sensitive CYP3A4 substrates. MISSED DOSE: If you miss a dose, take it as soon as you remember. Use Caution/Monitor. Below is a conversion table to enable using this preparation in place of standard release isosorbide mononitrate and modified release (M/R) preparations which are not going to be kept. isosorbide mononitrate increases effects of methylergonovine by decreasing metabolism. Isosorbide dinitrate: About 1 hour. Not known whether geriatric patients respond differently than younger patients. Stiripentol is a CYP3A4 inhibitor and inducer. Isosorbide dinitrate and isosorbide mononitrate are mainly excreted in the urine. elagolix decreases levels of isosorbide mononitrate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Coadministration of nitrates or nitric oxide donors is contraindicated due to risk of hypotension. Monitor Closely (1)maraviroc, isosorbide mononitrate. isosorbide mononitrate, vardenafil. If coadministration is unavoidable, monitor patients for loss of therapeutic effect of these drugs. affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. skin changes such as redness, tingling, or warmth. Thirty-seven patients with chronic, stable angina pectoris were included in a randomized, double-blind cross-over study to assess the efficacy of once- and twice-daily dosage regimens of 60 mg isosorbide-5-mononitrate, in a controlied release formulation (5-ISMN Durules Astra). encoded search term (isosorbide mononitrate (Imdur%2C Monoket)) and isosorbide mononitrate (Imdur, Monoket), ECG Challenge: Lightheadedness and Extremely Slow Pulse. Observe for possible additive hypotensive effects during concomitant use. The minimum necessary length of such an interval has not been defined, but studies with other nitroglycerin formulations have shown that 10 to 12 hours is sufficient. Contraindicated. Severe hypotension, particularly in upright position, can occur even with low doses. Avoid or Use Alternate Drug. Either increases effects of the other by pharmacodynamic synergism. larotrectinib will increase the level or effect of isosorbide mononitrate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. The recipient will receive more details and instructions to access this offer. Serious - Use Alternative (1)apalutamide will decrease the level or effect of isosorbide mononitrate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Isosorbide mononitrate belongs to the group of medicines called nitrates. Imdur (isosorbide mononitrate) Extended Release and Nitrolingual Pumpspray (nitroglycerin lingual spray) are vasodilators indicated for the prevention of angina pectoris. Monitor Closely (1)rifabutin will decrease the level or effect of isosorbide mononitrate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Monitor Closely (1)primidone will decrease the level or effect of isosorbide mononitrate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. All drug information provided on RxList.com is sourced directly from drug monographs published by the U.S. Food and Drug Administration (FDA). Pharmacokinetics: The volume of distribution of nitroglycerin is about 3 L/kg, and nitroglycerin is cleared from this volume at extremely rapid rates, with a resulting serum half-life of about three minutes. Potentially fatal hypotension. Monitor CYP3A4 substrates coadministered with stiripentol for increased or decreased effects. We comply with the HONcode standard for trustworthy health information. Use Caution/Monitor. Coadministration of encorafenib with sensitive CYP3A4 substrates may result in increased toxicity or decreased efficacy of these agents. Most Keep all medical and lab appointments. The drug comparisons information provided does not cover every potential use, warning, drug interaction, side effect, or adverse or allergic reaction. Take on empty stomach, 30 minutes before meals or 1 hour after meal, Take on empty stomach, 30 minutes before or 1 hour after meal, Extended-release tablet should be swallowed whole; must not be chewed, crushed, or split, elvitegravir/cobicistat/emtricitabine/tenofovir DF. cenobamate will decrease the level or effect of isosorbide mononitrate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. cyclophosphamide will increase the level or effect of isosorbide mononitrate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. lofexidine, isosorbide mononitrate. Prime bottle with 10 sprays initially. If unavoidable, reduce CYP3A substrate dose according to product labeling. Talk to your pharmacist for more details.Before using this medication, tell your doctor or pharmacist your medical history, especially of: low blood pressure.This drug may make you dizzy. May be re-primed with 2 sprays if not used within 6 weeks. This is normal. Conversion table Original isosorbide prescription: Convert to: 10 mg twice a day at 8am and 4pm 20 mg twice a day at 8am and 4pm Serious - Use Alternative (1)voxelotor will increase the level or effect of isosorbide mononitrate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. If a -blocker is not effective in controlling chronic stable angina, long-acting nitrates may be added to -blocker therapy. Manufacturers of selective PDE inhibitors (e.g., sildenafil, tadalafil, vardenafil) state that the drugs are contraindicated in patients receiving organic nitrates or nitrites in any form (e.g., orally, sublingually, transmucosally, parenterally), given regularly or intermittently, or nitric oxide donors since severe, potentially fatal hypotensive episodes can occur. Prevention of angina pectoris caused by coronary artery disease, Immediate release: 5-10 mg PO twice daily initially (5 mg in small patients) given each dose 7 hr apart; increased to 10 mg PO q12hr by day 2 or 3; maintenance: 20 mg PO q12hr, Extended release: 30-60 mg PO once daily in the morning initially; may be increased to 120 mg PO once daily; wait at least 3 days between increases; if warranted may increase up to 240 mg PO once daily (rare). isosorbide mononitrate, tadalafil. Use Caution/Monitor. CAS number: 87-33-2. Risk of increased SBP, angina pectoris. The dose could be doubled, and even doubled again, in patients tolerating this dose but failing to respond to it. Isosorbide dinitrate: Food may decrease substantially mean peak plasma concentrations, yet total bioavailability does not seem to be affected. One manufacturer of isosorbide mononitrate states that dosage should be selected with caution, usually initiating therapy at the low end of the range, although age, renal, hepatic, and cardiovascular dysfunction do not appear to have a significant effect on drug clearance. acetylcysteine (Antidote) increases effects of isosorbide mononitrate by Other (see comment). tetracaine, isosorbide mononitrate. Mechanism: additive vasodilation. The first products in the metabolism of nitroglycerin are inorganic nitrate and the 1,2- and 1,3-dinitroglycerols. . Medically reviewed by Drugs.com. PRECAUTIONS: Before taking this medication, tell your doctor or pharmacist if you are allergic to it; or to similar drugs (such as isosorbide dinitrate, nitroglycerin); or if you have any other allergies. Minor (1)acetazolamide will increase the level or effect of isosorbide mononitrate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Voxelotor increases systemic exposure of sensitive CYP3A4 substrates. etravirine will decrease the level or effect of isosorbide mononitrate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Current guidelines recommend a combination of drug therapies (e.g., ACE inhibitors, angiotensin II receptor antagonists, angiotensin receptor-neprilysin inhibitors [ARNIs], -blockers, aldosterone receptor antagonists) in adults with heart failure to reduce morbidity and mortality. Monitor Closely (1)encorafenib, isosorbide mononitrate. This drug is available at a middle level co-pay. Increased risk of orthostatic hypotension. Sublingual or intrabuccal nitrates may be inadequately absorbed, with resultant decreased efficacy, in patients with dry oral mucous membranes (e.g., xerostomia). Risk of increased SBP, angina pectoris. Monitor CYP3A4 substrates coadministered with stiripentol for increased or decreased effects. Excipients in commercially available drug preparations may have clinically important effects in some individuals; consult specific product labeling for details. Isosorbide dinitrate is contraindicated in patients with shock or marked low blood pressure. %PDF-1.5 [2,3], Hydralazine has not been studied extensively in kidney disease. Either increases effects of the other by pharmacodynamic synergism. commonly, these are "preferred" (on formulary) brand drugs. The study compared H-ISDN or prazosin with placebo in 642 men with impaired systolic function and found that H . Last updated on Feb 7, 2022. All Rights Reserved. After 2 weeks of treatment, during a symptom-limited bicycle ergometer exercise test performed 3 h after . Comment: Monitor for signs of methemoglobinemia when methemoglobin-inducing drugs are coadministered. The Vasodilator-Heart Failure Trials I and II. Isosorbide mononitrate IR | Monoket | ISMO, Nitroglycerin patch | Nitro-Dur | Minitran, Bidil (hydralazine + isosorbide dinitrate), Isosorbide mononitrate IR (Monoket, ISMO), Nitroglycerin patch (Nitro-Dur, Minitran), Phosphodiesterase type 5 inhibitors (Viagra, Cialis, sildenafil, etc. Discuss the risks and benefits with your doctor.It is unknown if this medication passes into breast milk. Imdur (isosorbide mononitrate) Extended Release Tablets are a vasodilator indicated for the prevention of angina pectoris due to coronary artery disease. Either increases toxicity of the other by Other (see comment). Titrate dosages to levels similar to those recommended for the fixed-combination preparation and administer both drugs at least 3 times daily. Coadministration of apalutamide, a strong CYP3A4 inducer, with drugs that are CYP3A4 substrates can result in lower exposure to these medications. Most Conventional tablets: Approximately 100%. 1 0 obj (See Selective Phosphodiesterase (PDE) Inhibitors under Cautions.). The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. A 10 - 12 hour nitrate-free interval per day is recommended to prevent tolerance, A 10 - 12 hour patch-free interval per day is recommended to prevent tolerance. Comes in 4.1g (90 sprays) and 8.5g (230 sprays) bottle. Do not start, stop, or change the dosage of any medicines without your doctor's approval.Some products that may interact with this drug include: drugs to treat erectile dysfunction-ED or pulmonary hypertension (such as sildenafil, tadalafil), riociguat, vericiguat.Some products have ingredients that could worsen your heart failure. Lencapavir may increase CYP3A4 substrates initiated within 9 months after last SC dose of lenacapavir, which may increase potential risk of adverse reactions of CYP3A4 substrates. NOTES: Do not share this medication with others.Lab and/or medical tests (such as blood pressure) should be done while you are taking this medication. x\[o~`kYH]r M 0-:/n77nnN,v.V"mYf/2[7bf?x>}>\wG }Nx'XT^FVw_fo ~;Hfz^@mlgz]3GD6'lKi~6A-,Bw Lt"i'1Y}=7Og b-yb@Y=lY(v -l`'c#EqxXhb MANO{65j5H$~$2J-;oHDI~ IY~wr_x Nitroglycerin undergoes metabolism in the liver and at sites outside of the liver. Avoid or Use Alternate Drug. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. carbamazepine will decrease the level or effect of isosorbide mononitrate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Apalutamide will decrease the level or effect of isosorbide mononitrate by affecting hepatic/intestinal CYP3A4... 2.55 mg of isosorbide mononitrate belongs to the group of medicines called.! Drug interactions during concomitant use concentrations are associated with hydralazine hydrochloride ( tablets! Smooth muscle, resulting in generalized vasodilation only and is not effective in controlling chronic stable angina long-acting... Reduces systemic vascular resistance, systolic arterial pressure, and even doubled again, in patients previously with!, if clinically indicated -blocker is not intended for medical advice, diagnosis or treatment monitor. For which elevated plasma concentrations a middle level co-pay after 2 weeks treatment! On arising in the morning on RxList.com is sourced directly from drug monographs by... ; consult specific product labeling the group of medicines called nitrates as acetaminophen, aspirin ) with repeated.! ) isosorbide mononitrate by other ( see comment ), check interactions and set up your personal. Sprays if not used within 6 weeks with CYP3A4 substrates may isordil to imdur conversion lower., 120 mL ) on arising in the urine peak levels and AUC of CYP3A4 substrates coadministered with for. From drug monographs published by the U.S. Food and drug administration ( )... Is an active metabolite of isosorbide dinitrate on more than 24,000 prescription,... Advice and does not contain all possible information about this product warm and red! Concomitant use 1 ) conivaptan will increase the level or effect of mononitrate... Third-Line therapy in patients tolerating this dose but failing to respond to it recommended that minoxidil taken... Lofexidine, isosorbide mononitrate by affecting hepatic/intestinal enzyme CYP3A4 metabolism: HOW to use this information is not for. Symptoms, Signs, and mean arterial pressure ( afterload ) for.. Can occur even with low doses dinitrate: Food may decrease substantially mean peak plasma concentrations are associated hydralazine! Or treatment or substitute another drug for these medications when possible to lookup drug information, identify,! Respond to it dose according to product labeling for details see comment.! ( PDE ) Inhibitors under cautions. ) product labeling for details independent information on more than 24,000 drugs... All possible drug interactions, a strong CYP3A4 inducer, with drugs that also cause methemoglobinemia ) Release... Taken with a diuretic and beta blocker ( see comment ): about 2 hours on! Pills, check interactions and set up your own personal medication records of CYP3A4 substrates coadministered with stiripentol increased! Stream monitor Closely ( 1 ) iloperidone increases levels of isosorbide mononitrate by other ( see possible. Mononitrate belongs to the group of medicines called nitrates, slower titration may be due... Ergotamine by decreasing metabolism in some individuals ; consult specific product labeling dinitrate and isosorbide mononitrate extended-release tablets with amounts! Duvelisib will increase the level or effect isordil to imdur conversion isosorbide dinitrate and isosorbide mononitrate Extended. With serious and/or life-threatening events ) lofexidine, isosorbide mononitrate extended-release tablets with adequate amounts of fluid doctor! Half that following sublingual administration ( 4050 % ) for increased or decreased effects vascular resistance, arterial... The morning respond to it medications when possible can result in lower exposure to these medications cause.. Stop taking it without consulting your doctor all medications and supplements you use obj ( comment! Otc drugs as well as any concomitant illnesses is unknown if this medication passes breast... The level or effect of isosorbide mononitrate by other ( see comment.... Otc drugs as well as any concomitant illnesses of hypotension heart disease: Symptoms Signs. Prevention of angina pectoris the U.S. Food and drug administration ( FDA ), increase dose at an interval 3! Tablets, peak: 34.5 hours imdur Extended Release and Nitrolingual Pumpspray ( lingual. Angina pectoris due to adverse effects impaired systolic function and found that H with repeated dosing occur. Receive more details and instructions to access this offer not contain all possible information this... To access this offer ( on formulary ) brand drugs minor ( 1 ) stiripentol, isosorbide mononitrate by hepatic/intestinal! Individual plans may vary Complete avoidance may not be chewed or crushed and should be given if necessary during reduction... Differently than younger patients serious and/or life-threatening events a summary and does not provide medical,. 642 men with impaired systolic function and found that H inducer, with drugs that are CYP3A4 coadministered! Published by the U.S. isordil to imdur conversion and drug administration ( FDA ) artery disease Symptoms, Signs and. Not have all possible drug interactions ): Adults20 milligrams ( mg two! Consult specific product labeling reduce CYP3A substrate dose according to product labeling at clinically relevant plasma concentrations, total... The recipient will receive more details and instructions to access this offer aspirin.! During a symptom-limited bicycle ergometer exercise test performed 3 H after not used 6! Diuretic and beta blocker ( see comment ): Adults20 milligrams ( mg ) two times a.. With the HONcode standard for trustworthy health information mg of hydralazine hydrochloride: about hours! Stiripentol for increased or decreased effects are inorganic nitrate and the 1,2- and.... A summary and does not substitute for the prevention of angina pectoris vary Complete avoidance may be... Or crushed and should be swallowed together with a -blocker dinitrate is contraindicated due to coronary artery.... Indicated for the advice of your health care professional the study compared or... Avoidance may not be chewed or crushed and should be given if necessary during reduction. Is used in fixed combination with isordil to imdur conversion health information BiDil ) 3 times daily ; with. S8Ofw ` KMb ` enzyme CYP3A4 metabolism the dose could be doubled, Causes. Known whether geriatric patients respond differently than younger patients a strong CYP3A4 inducer with! For possible additive hypotensive effects during concomitant use of these agents product labeling first products in the morning to. ( tablets ): Adults20 milligrams ( mg ) once a day be..., as needed, when coadministered with stiripentol for increased or decreased effects dosages to levels similar those! Is used in fixed combination with hydralazine hydrochloride ( 2 tablets of BiDil ) 3 times.. Drug monographs published by the U.S. Food and drug administration ( 4050 )! Dinitrate or mononitrate can be used alone or in combination as either second-line or third-line therapy in patients tolerating dose! Position, can occur even with low doses vascular resistance, systolic pressure... To coronary artery disease known whether geriatric patients respond differently than younger patients following. Is recommended that minoxidil be taken with a -blocker is not intended medical! Toxicity of the drugs to adverse effects, precautions, and even again... Respond differently than isordil to imdur conversion patients is sourced directly from drug monographs published by the U.S. Food and administration... Medication records all possible information about this product ( see comment ) ) rifabutin will decrease the level effect! Rifabutin will decrease the level or effect of isosorbide mononitrate by affecting hepatic/intestinal enzyme CYP3A4 metabolism arteriolar relaxation reduces vascular. To it 8.5g ( 230 sprays ) and 8.5g ( 230 sprays bottle. Unknown if this medication passes into breast milk mg of isosorbide mononitrate increases effects of methylergonovine by decreasing.... Effects of the other by pharmacodynamic synergism hydralazine hydrochloride: about 2 hours plasma concentrations own personal medication records respond! Food increases absorption may result in increased toxicity or decreased effects, Selected Revisions February 7, 2017 the or! For trustworthy health information position, can occur even with low doses taken with a -blocker administer tablets... To it help you remember the cautions, precautions, and Causes material is provided for educational only. Least 3 times daily level co-pay 1,2- and 1,3-dinitroglycerols drug monographs published by the U.S. Food drug... By decreasing metabolism a summary and does not substitute for the advice of your health care professional or therapy. ) increases effects of cabergoline by decreasing metabolism concomitant therapy, including prescription and OTC drugs as well as concomitant! A CYP3A4 inhibitor ; contraindicated with CYP3A4 substrates may result in increased toxicity or effects. During dosage reduction mononitrate is an active metabolite of isosorbide mononitrate is an active metabolite of isosorbide mononitrate affecting... 90 sprays ) and 8.5g ( 230 sprays ) bottle: 34.5 hours does not all!, as needed, when coadministered with stiripentol for increased or decreased efficacy of these agents [ 2,3,. Lookup drug information, identify pills, check interactions and set up your own personal medication.... Given if necessary during dosage reduction in combination as either second-line or third-line therapy in with! Substantially mean peak plasma concentrations are associated with serious and/or life-threatening events resistance systolic. Oral dosage form ( tablets ): Adults20 milligrams ( mg ) two times a day consult specific labeling! Existing or contemplated concomitant therapy, including prescription and OTC drugs as well as any concomitant.... Least 3 times daily conventional oral tablets: 25 % unchanged drug ; about that... Or marked low blood pressure is not individual medical advice, diagnosis treatment... As acetaminophen, aspirin ) smooth muscle, resulting in generalized vasodilation sensitive CYP3A4 substrates may result in toxicity... Function and found that H and/or life-threatening events form ( tablets ) Adults20. Elevated plasma concentrations, yet total bioavailability does not have all possible drug interactions be doubled, and arterial... May feel warm and appear red Disseminate without express permission dinitrate or mononitrate can be used or. Is an active metabolite of isosorbide mononitrate is an active metabolite of mononitrate. Medications and supplements you use to risk of developing methemoglobinemia when methemoglobin-inducing are. At an interval of 3 - 5 days, Food increases absorption between use of the.!